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The findings are attention-grabbing not only because of the size of the dataset, but because they suggest these agents may have effects that extend beyond glycemic control and weight loss

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More receptor coverage = synergistic effects Appetite suppression (via Y2R) layered onto glycemic control & energy expenditure Smart design: lipidation, sequence grafting, and biasing GLP-1R signaling toward cAMP while avoiding -arrestin desensitization These arent just incremental add-ons

Exenatide is also resistant to degradation by DPP-4 because it has Gly8 in the place of Ala8, the residue on which DPP-4 acts