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39 In earlier studies of modest weight reduction by nonpharmacologic caloric restriction, declines in lean mass typically accounted for 10%30% of the total body weight reduction

In accordance with these conditions, institutional review board (IRB) approval and informed consent were not required

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This study provides insight into how differential dynamics of peptideligand engagement with the GLP-1R TMD can promote differences in G protein-mediated signalling, improving molecular understanding of mechanisms that contribute to ligand-dependent differential efficacy at the GLP-1R