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Use of the injections started increasing in 2022, followed by "a sharp increase" in 2024

Currently pregnant, breastfeeding, or actively trying to become pregnant 2

Statements made about ingredients or outcomes reflect public discussion and historical usage only, and are not endorsed by medical professionals or regulatory agencies

The conjugate research and much of the mechanistic work described here remains preclinical, conducted in animal models and cell systems rather than in human clinical trials

PMID: 39266553 Arch Pharm Res Tirzepatide mitigates atherosclerosis progression and modulates oxLDL-mediated proatherogenic effects in macrophages: evidence for M1/M2 homeostasis restoration