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In this study, we established that human GPR17 shares similar signaling properties and functions to inhibit GLP-1 secretion, further validating it as a potential target for diabetes and obesity therapy

Digestion (2011) 83(Suppl 1):138.10.1159/000323399 21 ChoiSLeeMShiuALYoSJHalldnGAponteGW
They are calling it retatrutide, known as a triple-antagonist, because of it how mimics three different metabolic hormones

Glucagon secretion occurs by exocytosis of secretory granules triggered by Ca 2+ entry via voltage-gated calcium channels (VGCCs) [48]
