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GLP-1 drugs and DPP-4 inhibitors (gliptins) both manage diabetes by controlling metabolism, but the Cleveland Clinic study found that GLP-1 drugs are more potent, have stronger anti-inflammatory properties, and reduce cancer risk more effectively

Halloum W, Dughem Y Al, Beier D, et al

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Further, despite internal resistance at Novo, Knudsen initiated trials administering a higher dose of liraglutide (Saxenda) for the treatment of obesity

Unlike GLP-1R, Gipr and GIPR mRNA are widely expressed within the ventricular and atrial myocardium of both rodents and humans (Hiromura et al