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mTOR: mechanistic target of rapamycin

To reduce propionate synthesis, two main approaches have been reported: (1) Antibiotics: These are used to inhibit gut microbiota, thereby reducing microbial production of propionate, and (2) Carnitine supplementation: Propionyl-CoA can be converted to propionylcarnitine by carnitine acetyltransferase or to propionate by propionyl-CoA hydrolase, both of which help regulate cellular propionyl-CoA levels

In contrast, carnitine may benefit those in a calorie deficit for weight loss or seeking improved endurance

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The L-isomer is the biologically active form utilized by the human body, while the D-isomer is either inactive or can potentially inhibit the function of L-carnitine