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Importantly, these body weight changes were not attributable to differences in food intake across the groups, as all treatments showed similar food consumption patterns in both lean and obese mice

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doi: 10.3389/fncel.2022.895871

Its important to understand lipohypertrophy because it can cause variable insulin absorption resulting in unexplained high and low blood glucose (bg), and really cause problems, including a visit to the ER
NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability
