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A study showed that increased plasma iron levels in FPN mutant mice led to decreased osteogenesis, indicating a negative regulatory role of ferroportin in osteoclasts (86, 87)

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Nicotine affects the functional activity of ion transporters, including Na + , K + , 2Cl cotransporter and Na + , K + -ATPase on BECs and inhibits P-gp activity in the CNS (Paulson et al., 2006