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10.1016/j.cbpa.2018.07.014

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Initially, these aldehydes were believed to produce only cytotoxic effects associated with oxidative stress (by inducing molecular damage and damaging cellular responses based on inflammatory responses, changes in gene expression and apoptosis) [10], but as depicted above, evidence is increasing in the sense that these compounds can also have specific signaling roles inducing adaptive responses driven to decrease oxidative damage and improve antioxidant defences