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Doing it wrong can cause bruising, bleeding, or even infection

The Mn SOD SOD2 localizes to the mitochondrial matrix (Slot et al., 1986)
Sama MA, Mathis DM, Furman JL, Abdul HM, Artiushin IA, Kraner SD et al (2008) Interleukin-1-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/nfat activity

Yang, H., Ye, D., Guan, K.-L

This results in lactic acid accumulation, cytokine release, and free radical generation (Hakiminia et al., 2022)