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Current phase 2 and 3 clinical trials have shifted focus to other interventions targeting tauopathy, synaptic plasticity, neuroprotection, and/or inflammation [11]
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Combining both may influence separate enzymatic pathways that help sustain cellular NAD+ availability.* Research from leading institutions such as Washington University School of Medicine and peer-reviewed longevity studies continue to explore how NAD+ precursors influence metabolic and cellular health
The metabolite analysis demonstrated that Nrf2 strongly promotes purine nucleotide synthesis, resulting in the increased production of purine nucleotides
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