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In both cases, the data are insufficient to support clinical claims

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In general, men whose total testosterone levels are around 300400 ng/dL or lower and who have corresponding symptoms may be candidates for TRT or other hormone optimization therapies

Results typically last six months to a year, so patients usually schedule annual refreshers to maintain optimal results

The risk is much higher in men and women with gonadal dysgenesis, specially forms that arise from early gonadal differentiation defects, such as mutations in SRY and WT1, than in individuals with ovotesticular DSD or with hormone synthesis or action disorders (for example, androgen insensitivity) [168,169,170]