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This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

Intranasal cyanocobalamin therapy is not ideal for patients with chronic nasal symptoms or significant nasal pathology

In agreement with their single-drug effects, both (M+D)/2 and (M+D+V)/3 downregulated proteins linked to mitochondrial ATP synthesis and cell cycle ( Supplementary Figures S5 , S6

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