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doi:10.1177/02698811211032475

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

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Similarly, if Cu 2+ weakly bound to the sulfur atom of Met35 is the recipient of an electron from this S-atom to form the reduced Cu + (see above for discussion of a relatively weaker electron pair interaction with the S-atom protons in a polypeptide with -helical structure), this latter moiety can lead to the highly reactive hydroxyl free radical by Fenton chemistry as noted, initiating lipid peroxidation