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Systemic Inflammatory Response Shock-like Reaction A recent (2025) case report described a patient who developed full-blown systemic inflammatory response syndrome (SIRS) after a high-dose, unregulated glutathione infusion for cosmetic skin-lightening

[DOI] [PubMed] [Google Scholar] 601.Mayes C

12/15-lipoxygenase inhibition attenuates neuroinflammation by suppressing inflammasomes

Together, these metabolic alterations point to a state of energetic stress and compromised mitochondrial function in the sgPHD2 and sgGSTP1 double knockout, with secondary effects on cellular redox balance

doi: 10.1016/j.ecoenv.2024.117397 181 WeiZHaoCHuangfuJSrinivasaganRZhangXFanX