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Description
cholesterol trafficking

Starting from 8 weeks of age, mice were fed the MASH diet (Research Diets, D17010103) ad libitum for 24 weeks

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ATF4 is crucial for cells adapting to adverse conditions of amino acid deprivation and mediates a variety of cellular phenotypic changes (85)
Moreover, its generation involves the autophagylysosome route and is inhibited when this pathway is blocked, thus unveiling an anti-inflammatory role for ribosomal RNA and lysosomes, engaged at the onset of stress
