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To elicit evoked responses, electrical stimulation was delivered using a parallel bipolar electrode (FHC) and a constant current unit (WPI A385) coupled with a Master-8 controller (A.M.P.I.)

p r ) Representative whole dorsal striatal images of SST immunofluorescence from Trkb Penk-WT control ( p ), Trkb Penk-KO mutant injected at 3 M with Gsto2 -shRNA ( q ) or scrambled-shRNA ( r ) in the striatum and analysed at 8 M

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Although generally safe, injections should be used with caution in people with a history of allergic reactions to cobalamin or in people with Leber's disease (hereditary optic neuropathy), as B12 may worsen the condition