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Honestly, I feel like everyone that gets severe acne as a reaction should go to the derm as fast as possible because it seems like it can go on or get out of control for an indefinite amount of time

However, more human clinical trials are still needed

Most participants who experienced nausea during the initial titration phase reported significant improvement or complete resolution by weeks 4 to 8 at a stable dose
Van Itallie CM, Fanning AS, Bridges A, Anderson JM

Saric 2005
