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When B12 levels are low, the signs can be varied: Anemia: fatigue, weakness, pale skin, and dizziness Fatigue: a deep-seated weariness that doesn't improve with rest Nerve Damage: tingling or numbness in hands and feet, balance problems, and memory loss (seek medical advice promptly) Mood Disturbances: depression, irritability, and personality changes Who Is Most at Risk for B12 Deficiency

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232 Nrf2 not only regulates oxidative/xenobiotic stress response but also represses inflammation by opposing transcriptional upregulation of a number of pro-inflammatory cytokine genes

Adv Nutr 2015;6(6):660-664