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free systemic TB-4 at matched total doses produced zero cardiac functional improvement vs locally-targeted nanoparticle formulations: PubMed 12581423 TB-4 / TB-500 product mislabeling documented bidirectional mislabeling between full-length TB-4 (43 aa) and the TB-500 fragment (residues 1723) in marketed peptide products: Esposito M et al