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The ability of CB1 antagonists such as rimonabant to reduce the rewarding properties of several drugs of abuse and inhibit reinstatement of drug seeking following abstinence led to the idea that CB1 receptor blockade could be a viable therapeutic approach for treating drug use disorders (reviewed in Justinova et al., 2009)
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Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway
However, Ipamorelin and GHRP-6 are often preferred
