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MT-IIs activation of MC3R and MC4R in mesolimbic dopamine circuits , including the ventral tegmental area and nucleus accumbens and modulates dopamine release and dopamine receptor signalling in reward and motivation circuits
For Melanotan 1: The clinical data is most reassuring in the EPP population, where the risk-benefit profile has been formally evaluated
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It promotes mitochondrial -oxidation, which is crucial for balanced cardiac energy metabolism, and has cardioprotective effects by reducing oxidative stress, inflammation, and necrosis of cardiac myocytes
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