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Due to the heterogeneity of the molecules considered and the laboratory methodologies, it was not possible to perform a meta-analysis, and the main results are reported in Table 1

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Figure 2A clearly demonstrates the use of human artificial chromosome (HAC) vectors to develop Caco-2 cells co-expressing CYP3A4 and CYP450 reductase (CPR) (Takenaka et al., 2017)
