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Hottinger for editorial support and the following for support of their research programmes: the US National Institutes of Health (R01AI045898, R37AI045898, R01AI057803, R01AI061097, R01AI083450, R01DK076893, U01AI088806, U19AI070235, U19AI066738, P01HL076383 and K12HD028827)

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R., Haddadi, M., Shivanandappa, T

ICD inducers can be categorized based on their immune induction mechanisms: Type I inducers primarily comprise genotoxic agents that lead to abnormal protein activation and DNA damage, while Type II inducers are generally more potent, inducing endoplasmic reticulum oxidative stress, perturbing ER homeostasis, raising intracellular Ca2+ levels, and rapidly activating danger signal pathways to expose and release DAMPs (137139)

If it means showing a clean preclinical toxicology profile and early human tolerability data in a narrow set of conditions, it occupies a grey experimental zone -- one that requires informed clinical oversight, an honest accounting of what is unknown, and a high tolerance for uncertainty