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At the post-translational level, just as CBP/p300-mediated acetylation of Lys within the Neh1 domain increasing NRF2-dependent transcription, SIRT1 mediates Lys deacetylation, antagonizing the NRF2 signal [234]
Agostini F, Bubacco L, Chakrabarti S, Bisaglia M

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The most common dose was 2400 mg (1200 mg twice daily)

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
