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LIN28A can activate AR via c-mycregulation and promotes malignancy of ER-/Her2 + BC [63], thus providing strong evidence that curcumin can directly or indirectly interact with androgen signaling pathways and can affect tumor progression by regulating androgen signaling

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+ , Ca 2+ , and Na + currents, the suppression of I K1 was found to contribute to less to RMP depolarization than that of LCAC-mediated NKA inhibition (Shen and Pappano, 1997)