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doi: 10.1089/thy.2000.10.1043

Abbreviations SNP: Single nucleotide polymorphism TMA: Trimethylamine TMAO: Trimethylamine N-oxide TMAU: Trimethylaminuria References Humbert JA, Hammond KB, Hathaway WE

Mutations or inhibitions of human FMO3 that prevent TMAO production can lead to the accumulation of TMA, which is excreted in excess in urine, sweat, and breath, smelling like rotten fish (Zeisel and Warrier, 2017)

Answer: Many supplements have been evaluated for their effects in treating fibromyalgia, a condition characterized by tender muscles, fatigue, and sleep disturbances and that is often treated with antidepressants