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Besides the previously detailed biomarkers, endothelial cells synthesize plasminogen-activator inhibitor 1 (PAI-1), a marker of endothelial cell activation
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D.RobelloC.et al
Patients with FM commonly use long-term pharmacotherapy, including analgesics (e.g., NSAIDs, opioids), antidepressants (e.g., SSRIs, SNRIs such as duloxetine and milnacipran), and occasionally antibioticsall of which are well-established modulators of the gut microbiome
