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The glutathione system is a central component of cellular antioxidant defense
FIGURE 6 FIGURE 7 Glutathione Peroxidase 1 Inhibits the NF-B Pathway to Protect Against Peroxynitrite-Induced Spiral Ganglion Neurons Damage The transcription factor NF-B plays a vital role in cellular death and survival under oxidative stress conditions (Schneider et al., 1999
Cholesterol metabolism in neurodegenerative diseases: Molecular mechanisms and therapeutic targets
Although H 2 O 2 is not a free radical, it is able to produce reactive ROS hydroxyl ion (OH) via HaberWeiss or Fenton reaction
