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While numerous studies have demonstrated the antidepressant and neuroprotective effects of exercise and polyphenols individually, their combined effects remain underexplored, particularly in clinical populations

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Guruvayoorappan C, Kuttan G (2008) Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice

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Improvements were also observed in gastrointestinal symptoms and behavioral problems after the intervention [52]