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For example, the PG-based PROTAC 112 (SJ995973) targeting BRD4 protein (DC 50 value of 0.87 nM) was shown to reduce cell viability in human AML MV4-11 cells at the order of picamolar (IC 50 value of 3 pM), corroborating the advantages of incorporating PG derivatives in the construction of innovative and more stable cereblon-based PROTACs 155

Siller-Matula et al., 2011

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Unlike traditional human growth hormone (HGH) therapies that can cause more serious problems like joint pain, insulin resistance, and an increased risk of diabetes, AOD 9604 specifically targets fat metabolism

10, eaap8914
