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Subcutaneous administration appears most common in published protocols, though intramuscular, intraperitoneal (in animal models), and even oral routes have demonstrated efficacy

Trends Pharmacol Sci 30:581591 Zhang P, Yang M, Chen C, Liu L, Wei X, Zeng S (2020) Toll-like receptor 4 (TLR4)/opioid receptor pathway crosstalk and impact on opioid analgesia, immune function, and gastrointestinal motility

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