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31 Courtesy of Dr Paola Bianchi
Vitamin D obtained from sun exposure, food, and supplements is biologically inert and must undergo two hydroxylations in the body for activation
Therefore, STARD7 expression is not regulated by Wnt signaling in colon cancer-derived cell lines as well as in mouse IECs but promotes the expression of Wnt effectors in established colon cancer cell lines
Collectively, genetic alterations within the p53/MDM2/p14ARF pathway, including p53 mutations, MDM2 amplification, and p14ARF deletions, constitute major drivers of GBM pathogenesis
10.1159/000324934 69 SanzA
