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These mediators stimulate fibroblast proliferation and extracellular matrix deposition while promoting M2 macrophage polarization, collectively accelerating pulmonary fibrogenesis ( 2.5 Oxidative stress, ferroptosis and DNA damage RCS-adsorbed Fe 2+ catalyzes hydroxyl radical (OH) generation via Fenton reactions, triggering dysregulated intracellular redox homeostasis characterized by ROS overaccumulation ( Figure 1 )

Ketogenic diets have been shown to reduce body weight, improve insulin sensitivity, and lower androgen levels, which can alleviate symptoms such as hirsutism and acne [166]

Additionally, the modulation of cystine-glutamate exchange via the system x c has been suggested as a new strategy to diminish the excitatory glutamatergic transmission observed after drugs of abuse, while drugs that influence that systemsuch as N-acetylcysteine (NAC)were considered as promising targets for the development of novel pharmacotherapies of SUD