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There is very little existing information on most of these peptides, he says, let alone on what happens if they are combined

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Statistical analysis Cell proliferation and survival experiments were independently performed for three times, following the principle of repeatability

Exposure to excessive ROS, including free radical superoxide O 2 - , hydrogen peroxide, and hydroxyl radicals, favors oxidative stress, alters mitochondrial Ca 2+ homeostasis, triggers membrane lipid peroxidation and potentially induces nuclear and mtDNA damage [15] .Sustained elevations in intracellular Ca 2+ concentrations ultimately cause neuronal degeneration and cell death by initiating apoptosis [16]

10.1038/s41574-023-00898-1 [DOI] [PubMed] [Google Scholar] 39.Zhang Y, Qian B, Yang Y et al (2024) Visceral adipocyte-derived extracellular vesicle miR-27a-5p elicits glucose intolerance by inhibiting pancreatic -cell insulin secretion