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Although TRPC1 alone functions as a SOCE in human adult retinal pigment epithelial-19 (ARPE-19) cells (Bollimuntha et al., 2005), TRPC3 and 4 only function as SOCE when co-expressed with TRPC1 (de Souza and Ambudkar, 2014)
Experimental injury, a surgical incision in the plantar aspect of the rat hind paw, leads to a remarkable reduction in paw withdrawal threshold to mechanical stimuli for several days, representing mechanical hyperalgesia [10]
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Secondary areas include cardiovascular protection and organ protection in toxicity models
