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Blood supply to the medulla is provided by the vasa recta , which have sluggish, low-volume blood flow resulting in a naturally hypoxic state
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PM may impair Treg function, reducing immune tolerance and promoting chronic inflammation

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With future studies in this area a greater understanding of IGF pathway activation will certainly lead to a resurrection of IGF targeted therapies in cancer but critically this time with an ability to identify the patients who will most benefit from it
