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In the EAE model, activated macrophages, monocytes, dendritic cells, as well as apoptotic oligodendrocytes release pathogen-associated molecular pattern or DAMP, like the high mobility group box protein-1 to the extracellular environment, and initiate an inflammatory response characterized by the activation of the inflammasome (Barclay and Shinohara, 2017

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Under physiological conditions, BBR is ionized and forms self-aggregates in acidic environments, such as the stomach, reducing solubility and intestinal permeability [15]

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