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And in a 2022 study of people with treatment-resistant bipolar depression, participants depression and functioning improved upon the reversal of insulin resistancea metabolic condition that is more common in people with bipolar disorder (J

Retatrutide's cardiovascular safety profile is still being established in ongoing trials

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Lixisenatide (Adlyxin), which is FDA-approved but no longer marketed in the US, has a half-life of about 3 hours

These results were so impressive that tirzepatide earned its own place in weight management: as of late 2023, the FDA has also approved it under the name Zepbound specifically for chronic weight management in obesity (making it officially indicated for weight loss, not just diabetes)