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Semaglutide has a half-life of about 7 days (168 hours), which is why you only need to inject once weekly

Notable exclusions include antibodies, label expansion, biosimilars

In SURMOUNT-1, the landmark trial for tirzepatide in weight management, participants without diabetes achieved the following results over 72 weeks: 5 mg dose: 16.0% average body weight reduction 10 mg dose: 21.4% average body weight reduction 15 mg dose: 22.5% average body weight reduction Read that again

A diagnosis of prediabetes (Hgb A1C between 5.7% and 6.4%, or similar fasting glucose values) does not automatically disqualify you, but it highlights the importance of effective weight management

For a broader look at hydration and weight loss, see Hydration for Health: Does Water Play a Role in Weight Loss