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Disruption of glucagonlike peptide 1 signaling in Sim1 neurons reduces physiological and behavioral reactivity to acute and chronic stress

Results for Eli Lilly's new Foundayo pill show participants lost 11.1% of their body weight, while results for the company's injectable Zepbound show an average weight loss of 20.2%

Location: Indianapolis, IndianaWarning Letter Date: September 9, 2025FDA Department Issuing Warning: Center for Drug Evaluation and Research (CDER)Type of Warning: False & Misleading Claims/Misbranded DrugsSubject of Violation: An Oprah Special: Shame, Blame, and the Weight Loss Revolution, regarding Zepbound (tirzepatide) and Mounjaro (tirzepatide)FDA Warning: In the program, which aired on television in 2024 and until recently was available continuously on the ABC website and through various streaming services, Eli Lilly promoted Mounjaro and Zepbound in a manner that failed to present the serious risks of these drug products in a truthful and nonmisleading manner, despite FDAs prior correspondence (advisory comments dated June 13, 2022 and June 21, 2022)

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For non-diabetic patients exploring GLP-1 therapy, understanding both your biomarkers (glucose, insulin, lipids) and your genetic context can support a more confident, evidence-informed discussion with your provider about whether this treatment approach is appropriate for you and what outcomes to expect