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"Triple Hormone Receptor Agonist Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease: a randomised, double-blind, placebo-controlled, phase 2a trial." Nature Medicine , 2024

In this episode of the Modern Thyroid and Wellness Podcast, host McCall McPherson welcomes renowned integrative physician Dr

Rather than targeting a specific substance, the drugs may be affecting the craving itself

Safety Profile and Side Effects Retatrutides side effect profile in Phase 2 trials was broadly consistent with other GLP-1 class therapies primarily gastrointestinal, primarily dose-dependent, and primarily manageable

Since an increase of [Ca 2+ ] i triggers GLP-1 release from intestinal L-cells 10 , and since L-cells express TRPA1 channels 9 , these findings indicated that JWU-A021 might serve as the prototype of a new class of small molecule GLP-1 secretagogues with TRPA1 channel activating properties