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A C20 fatty diacid moiety is attached to the lysine residue at position 17 through an AEEA-Glu linker, supporting albumin binding and an extended pharmacokinetic half-life in research models

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Potential Considerations for Co-Administration While direct interaction data for tirzepatide and topiramate is scarce, we can anticipate certain considerations based on their known profiles: Overlapping Weight Loss Mechanisms Both tirzepatide and topiramate contribute to weight loss, primarily through appetite suppression and increased satiety