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In particular, changes in specific microbial taxa and related metabolites may be associated with improved metabolism, inflammation, and vascular markers [3]

49 It is interesting that the double Aib substitutions led to comparable receptor binding and potency (IC 50 = 1.1 nM, EC 50 = 0.06 nM compared to GLP-1 (IC 50 = 1.5 nM, EC 50 = 0.08 nM)), whereas a single Aib at position 8 brought in a 4-fold decrease in potency and 2-fold increase in binding affinity

I found the study results not only interesting but also very much in accordance with one of the most frequently asked questions to me by health care providers: Whether persons with serious mental illness and/or substance use disorders (SMI-SUD) should be prescribed GLP-1 RAs specifically to treat their mental disorders

1 Since the late 1980s, however, the triumvirate has expanded to include additional core defects

Treatment for confirmed B12 deficiency includes oral cyanocobalamin for dietary causes or intramuscular hydroxocobalamin for malabsorption or neurological involvement, following NHS and BNF guidance