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The most frequently reported treatment-related adverse effects occurring with GLP-1 receptor agonists are gastrointestinal, primarily nausea (occurring in 2560% of patients in clinical trials), vomiting (515%), and diarrhea (1020%) (47)

Further, experimental data suggest that the pro-survival action of GLP-1RAs may also be mediated by the Akt-dependent stimulation of the mTORC1/S6K1 pathway, the activation of which is dependent upon the IGF-1R, as observed in rodent islet cells (44)

Our more-recent survey data allow us to examine whether GLP-1 use rates have changed since 2023

Testing these hypotheses merits future effort, as does reconsideration of the previous literature that has shown positive attributes of GIPR agonism for beta cell function 10,42,43

To properly discuss these concerns, its important to first understand how GLP-1 drugs actually work