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Despite this high prevalence and the progressive nature of the disease, therapeutic options remain limited

204 Mazdutide, a dual GLP-1/glucagon RA, and retatrutide, a triple GLP-1/GIP/glucagon RA, also have both shown significant weight loss effects in Phase 2 trials

2 The American Association of Clinical Endocrinologists and American College of Endocrinology 2015 guideline does, however, give preference to GLP-1RA and SGLT2-I over older medication classes including SU and TZD

The efficacy of microbiome depletion through ABX was validated through the quantification of bacterial load (Supplementary Fig

Finally, nine representative groups or species of the human gut microbiota were analyzed in feces