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Description
In this study, We examined 9-day body-weight changes post-discontinuation of semaglutide (after 4-week dose escalation: 0.33.0 nmol/kg/day) or Vutiglabridin (30 mg/kg) in DIO mice

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Doses typically start at 2 mg and increase gradually to 4, 8, or 12 mg over several weeks to help reduce the severity of side effects

Using rodent models of obesity and metabolic dysfunction, the research group demonstrated that the triple-agonist approach produced meaningful reductions in body weight and improved glycaemic parameters compared to both placebo and comparator compounds targeting fewer receptors
