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Retatrutide is an investigational triple receptor agonist peptide that simultaneously targets and activates the glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR)

In the phase 3 EVOKE(+) trials, semaglutide did not slow clinical progression of Alzheimers disease, but the findings provide new insights in the ongoing quest for treatments.

Cardiologists also had a greater tendency than the other specialties to give the International Non-proprietary Name (INN) of new GLP-1s, rather than the brand name.

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Some individuals may also experience decreased appetite, dyspepsia, or fatigue